Human Anti-Toxin Recombinant Antibody (clone LR); scFv Fragment
Clone LR was obtained after three cycles of directed evolution of the parental clone 3F and incorporating a V101F mutation into one of the derived variant clones (9004G). This antibody clone recognizes and neutralizes the main toxins from the venoms of the C. noxius and Centruroides suffusus suffusus scorpions (Cn2 and Css2, respectively), with affinities in the picomolar range, and removes any poisoning symptoms. In neutralization tests using fresh whole venom in mice, clone LR was capable of inhibiting nearly all symptoms caused by the C. suffusus suffusus venom.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-S0146-YC-S(P) |
| Pricing | Inquiry |
| Host | Human |
| Target | Toxin |
| Species Reactivity | C. noxius, C. suffusus suffusus scorpions |
| Type | Human scFv |
| Applications | Neut, FuncS |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |