IWP 12
IWP 12 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). It blocks post resection juvenile zebrafish tailfin regeneration and is suitable for in vivo assays. It is a membrane-bound O-acyltransferase (MBOAT) and activates Wnt proteins with IC50 value of 15 nM. It inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.
| Supplier | BOC Sciences |
|---|---|
| Product # | 688353-45-9 |
| Pricing | Inquire |
| Cas | 688353-45-9 |
| Molecular Weight | 418.56 |
| Molecular Formula | C18H18N4O2S3 |
| Canonical SMILES | CC1CC2=C(S1)C(=O)N(C(=N2)SCC(=O)NC3=NC4=C(S3)C=C(C=C4)C)C |