PF-06372222
PF-06372222 is a small-molecule negative allosteric modulator (NAM) of glucagon receptor (GCGR). Antagonists of GCGR may be helpful in treating type 2 diabetes mellitus because they regulate plasma glucose levels by decreasing or slowing hepatic glucose production by signaling in the liver, intestinal smooth muscle, kidney, brain, and adipose tissue. PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion and may also play a role in hormonal release leading to acute and chronic stress and anxiety. By negatively modulating GLP-1R, PF-06372222 could treat type 2 diabetes mellitus and stress and anxiety.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD368 |
| CAS # | 1407592-99-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | PF-0637222; PF0637222; PF 0637222 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H28F3N5O3 |
| Exact Mass | 515.2144 |
| Molecular Weight | 515.54 |
| Elemental Analysis | C, 60.57; H, 5.47; F, 11.06; N, 13.58; O, 9.31 |
| IUPAC/Chemical Name | (R)-3-(4-((3,3-dimethylcyclobutyl)((6-(4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-3-yl)amino)methyl)benzamido)propanoic acid |
| InChi Key | MYZIDYJMNWEJMC-QHCPKHFHSA-N |
| InChi Code | InChI=1S/C26H28F3N5O3/c1-25(2)11-18(12-25)23(16-3-5-17(6-4-16)24(37)30-10-9-22(35)36)33-19-7-8-21(31-13-19)34-14-20(32-15-34)26(27,28)29/h3-8,13-15,18,23,33H,9-12H2,1-2H3,(H,30,37)(H,35,36)/t23-/m0/s1 |
| SMILES Code | FC(F)(F)C1=CN(C2=CC=C(N[C@@H](C3=CC=C(C(NCCC(O)=O)=O)C=C3)C4CC(C)(C)C4)C=N2)C=N1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |