Pemetrexed, Disodium Salt, Heptahydrate (Alimta, LY-231514, MTA, Rolazar, Tifolar, CAS 357166-29-1), >99%

LC Laboratories' Product Number P-7177 - Pemetrexed, Disodium Salt, Heptahydrate (Alimta, LY-231514, MTA, Rolazar, Tifolar, CAS 357166-29-1), >99% - for research use only. Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7 nM, 109 nM and 9.3 µM, respectively. Pemetrexed inhibits the proliferation of various human tumor cell lines, including CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells. Thymidine demonstrated its greatest protective effect at the IC50 of pemetrexed. However, higher drug concentrations of pemetrexed required the combination of both thymidine plus hypoxanthine to protect the tumor cells. The addition of folic acid supplementation with some antifolates substantially diminished the host toxicity. However, natural folates inhibited the activity of pemetrexed by suppressing folylpolyglutamate synthetase and thus decreasing the levels of active folylpolyglutamate pemetrexed congeners. The membrane transport system for pemetrexed includes reduced folate carrier (RFC), folate receptors, a folate transport carrier with a low-pH optimum, and RFC-independent transport at neutral pH, etc. Pemetrexed was approved in combination with cisplatin for the treatment of pleural mesothelioma in 2004. Pemetrexed was also approved for the second-line treatment of locally advanced or metastatic non-small cell lung cancer in 2004. Pemetrexed is the active ingredient in the drug sold under the trade name Alimta®. This drug has been approved in at least one country for use in patients with pleural mesothelioma as well as non-small cell lung cancer. NOTE: The pemetrexed product sold by LC Laboratories is NOT Alimta® and is NOT for human use. Our pemetrexed product is the disodium salt heptahydrate, whose CAS number is 357166-29-1. The following CAS numbers correspond to other forms of pemetrexed: 137281-23-3 for the free acid; 150399-23-8 for the anhydrous disodium salt, and 357166-30-4 for the disodium salt "hemipentahydrate" (2.5 H2O). NOTE: Water content may vary from lot to lot. Please refer to the elemental analysis provided in the Certificate of Analysis to obtain the water content for each lot.

• Supplier: LC Laboratories
• Product #: P-7177
• Sku #: P-7177_1g