Aminooxyacetic Acid
Aminooxyacetic acid, often abbreviated AOA or AOAA, is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 µM) that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. AOAA is also an inhibitor of pyridoxal phosphate (PLP)-dependent enzymes, which serve as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes.
| Supplier | BOC Sciences |
|---|---|
| Product # | 645-88-5 |
| Pricing | Inquire |
| Cas | 645-88-5 |
| Molecular Weight | 91.07 |
| Molecular Formula | C2H5NO3 |
| Canonical SMILES | O=C(O)CON |