Ascomycin (Immunomycin; FK-520; FR-900520; L 683590; CAS 104987-12-4), >99%

LC Laboratories' Product Number A-1040 - Ascomycin (Immunomycin; FK-520; FR-900520; L 683590; CAS 104987-12-4), >99% - for research use only. Ascomycin (also known as Immunomycin, FR-900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases. Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Antimalarial effects of ascomycin appear to be independent of its immunosuppressive properties. FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. We note that one of our competitors, AG Scientific, as of February 3, 2014, is claiming 99.9% purity for its Ascomycin. This claim is not credible in general chemical terms for this complex organic compound, nor in terms of the sensitivity and reproducibility of generally utilized analytical techniques.

• Supplier: LC Laboratories
• Product #: A-1040
• Sku #: A-1040_25mg