L-368899 free base
L-368899 is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). L-368,899 HCl antagonizes oxytocin-induced uterine contractions in vitro and in vivo.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD456 |
| CAS # | 148927-60-0 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | L-368899 free base; L-368,899; L-368,899; L-368,899; L-368899; L-368899; L-368899. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H42N4O5S2 |
| Exact Mass | 554.2597 |
| Molecular Weight | 554.76 |
| Elemental Analysis | C, 56.29; H, 7.63; N, 10.10; O, 14.42; S, 11.56 |
| IUPAC/Chemical Name | (2R)-2-amino-N-((1R,4R)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide |
| InChi Key | MWIASLNTAGRGGA-OGUNDUEHSA-N |
| InChi Code | InChI=1S/C26H42N4O5S2/c1-19-7-5-6-8-22(19)29-12-14-30(15-13-29)37(34,35)18-26-11-9-20(25(26,2)3)17-23(26)28-24(31)21(27)10-16-36(4,32)33/h5-8,20-21,23H,9-18,27H2,1-4H3,(H,28,31)/t20-,21-,23?,26+/m1/s1 |
| SMILES Code | O=C(NC1[C@@](C2(C)C)(CS(=O)(N3CCN(C4=CC=CC=C4C)CC3)=O)CC[C@]2([H])C1)[C@H](N)CCS(=O)(C)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |