delta PKC (8-17); PKC d Inhibitor

Ask supplier a question | View on supplier's website
Supplier Creative Peptides
Product # X21142
Pricing Inquire
MolecularWeight 1116.2
Sequence
  • One Letter Code: SFNSYELGSL
  • Three Letter Code: H-Ser-Phe-Asn-Ser-Tyr-Glu-Leu-Gly-Ser-Leu-OH
Storage -20°C
Explanation This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.
Reference
  • 1. Bright, R. et al. J Neurosci 24, 6880 (2004).
  • 2. Tanaka, M. et al. Circulation 110, 194 (2004).
  • 3. Braun, M and D. Mochly-Rosen. J Mol Cell Cardiol 35 895 (2003).
  • 4. Chen, L. et al. Proc Natl Acad Sci USA 98, 11114 (2001).
Feedback