Cyclosporin A (Cyclosporine, Ciclosporin A, Ramhyphin A, Antibiotic S 7481F1, CsA, CAS 59865-13-3), >99%

LC Laboratories' Product Number C-6000 - Cyclosporin A (Cyclosporine, Ciclosporin A, Ramhyphin A, Antibiotic S 7481F1, CsA), >99% - for research use only. Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. The complex of cyclosporin A with the protein cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki = 270 nM). Inhibits interleukin-1α-, lipopolysaccharide-, and TNF-α-nitric oxide synthesis induction.

• Supplier: LC Laboratories
• Product #: C-6000
• Sku #: C-6000_25g