Human Anti-HIV-1 gp41 Recombinant Antibody (clone 4E10)

Recombinant Human Antibody (4E10) is capable of binding to HIV-1 gp41 transmembrane subunit, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp41 transmembrane subunit mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp41 transmembrane subunit mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This broadly neutralizing antibody could interact with membrane lipids, but the antibody regions contacting lipids and its orientation with respect to the viral membrane are unknown.

• Supplier: Creative Biolabs
• Product #: PABL-192
• Host: Human
• Target: HIV-1 gp41
• Species Reactivity: HIV-1
• Type: Human IgG
• Applications: WB, Neut, FuncS
• Storage: Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.