A-192621
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-120295-5 mg |
| CAS # | 195529-54-5 |
| Pricing | 5 mg, USD $380.0 |
| Biological Activity | A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level[1][2][3]. |
| Purity | ≥99.0% |
| MWt | 558.66 |
| Formula | C₃₃H₃₈N₂O₆ |