| Supplier |
Creative Peptides |
| Product # |
R1807 |
| CAS # |
187389-52-2 |
| Pricing |
Inquire
|
| LabelingTarget |
Pan-caspase
|
| BoilingPoint |
732.4±60.0 °C at 760 mmHg
|
| Synonyms |
Z-VAD (OMe)-FMK
|
| MolecularFormula |
C22H30FN3O7
|
| MolecularWeight |
467.49
|
| Source |
Synthetic
|
| Sequence |
- One Letter Code: ZVA-D(OMe)-FMK
- Three Letter Code: Z-Val-Ala-Asp(OMe)-CH₂F
|
| Storage |
Desiccate at -20°C
|
| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
|
| Explanation |
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.
|
| Application |
Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor.
|
| Activity |
Inhibitor
|
| InChI |
InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
|
| InChIKey |
MIFGOLAMNLSLGH-QOKNQOGYSA-N
|
| Solubility |
Soluble in DMSO
|
| IsomericSMILES |
C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
|
| Appearance |
White solid
|
| Purity |
>98.0%
|
| AreasOfInterest |
Cancer
|
| LongTermStorageConditions |
-20 °C
|