RO5263397 HCl
RO5263397 is a selective TAAR 1 agonist. RO5263397 was efficacious in reducing cocaine-mediated behaviors. RO5263397 dose-dependently prevented cocaine-induced lowering of ICSS thresholds. TAAR1 stimulation effectively suppresses the rewarding and reinforcing effects of cocaine in self-administration and ICSS models, supporting the candidacy of TAAR1 as a drug discovery target for cocaine addiction.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1707 |
| CAS # | 1357266-05-7 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | RO5263397; RO-5263397; RO 5263397. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C10H13Cl2FN2O |
| Molecular Weight | 267.1254 |
| Elemental Analysis | C, 44.96; H, 4.91; Cl, 26.54; F, 7.11; N, 10.49; O, 5.99 |
| IUPAC/Chemical Name | (S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine dihydrochloride |
| InChi Key | GZJSFLYZAYEEKB-KLQYNRQASA-N |
| InChi Code | InChI=1S/C10H11FN2O.2ClH/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9;;/h2-4,9H,5H2,1H3,(H2,12,13);2*1H/t9-;;/m1../s1 |
| SMILES Code | NC1=N[C@@H](C2=C(C)C(F)=CC=C2)CO1.[H]Cl.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |