Crinecerfont
Crinecerfont, also known as SSR125543, is a potent, selective, and orally active corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively). SSR125543 attenuates long-term cognitive deficit induced by acute inescapable stress in mice, independently from the hypothalamic pituitary adrenal axis. SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD173 |
| CAS # | 752253-39-7 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | SSR125543; SSR-125543; SSR 125543; SSR125543A; SSR-125543A; SSR 125543A; Crinecerfont |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C27H28ClFN2OS |
| Exact Mass | 482.1595 |
| Molecular Weight | 483.04 |
| Elemental Analysis | C, 67.14; H, 5.84; Cl, 7.34; F, 3.93; N, 5.80; O, 3.31; S, 6.64 |
| IUPAC/Chemical Name | (S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine |
| InChi Key | IEAKXXNRGSLYTQ-DEOSSOPVSA-N |
| InChi Code | InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1 |
| SMILES Code | C#CCN([C@H](C1=CC=C(C)C(F)=C1)CC2CC2)C3=NC(C4=CC(C)=C(OC)C=C4Cl)=C(C)S3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |