SOMCL-668
SOMCL-668 is a novel potent and selective allosteric modulator of sigma-1 receptor. SOMCL-668 not only attenuated acute PCP-induced hyperactivity and PPI disruption, but also ameliorated social deficits and cognitive impairment induced by chronic PCP treatment. Pretreatment with the selective sigma-1 receptor antagonist BD1047 blocked the effects of SOMCL-668, indicating sigma-1 receptor-mediated responses. in vivo lower dose of SOMCL-668 exerted positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084. Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1172 |
| CAS # | 1422251-09-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | SOMCL-668; SOMCL668; SOMCL 668; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H19NO |
| Exact Mass | 253.1467 |
| Molecular Weight | 253.345 |
| Elemental Analysis | C, 80.60; H, 7.56; N, 5.53; O, 6.32 |
| IUPAC/Chemical Name | 3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol |
| InChi Key | YQRZJWYKYUBPKB-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H19NO/c1-18-10-9-14-11-15(19)7-8-16(14)17(12-18)13-5-3-2-4-6-13/h2-8,11,17,19H,9-10,12H2,1H3 |
| SMILES Code | OC1=CC=C2C(CCN(C)CC2C3=CC=CC=C3)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |