SEP-174559
SEP-174559, also known as (S)-Desmethylzopiclone and (S)-DMZ, is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of anxiety and muscle spasticity. Micromolar concentrations of SEP-174559 potentiated GABA(A) receptor currents evoked by subsaturating concentrations of GABA. The potentiation was related to a leftward shift in the GABA dose-response curves, suggesting the drug acts to increase GABA binding affinity. SEP-174559 and its parent compound, racemic zopiclone, were not selective between alpha1-, alpha2-, or alpha3-bearing GABA(A) receptors. SEP-174559 did not affect serotonin type-3 receptor function but was found to inhibit nicotinic acetylcholine (nACh) receptors. SEP-174559 inhibited N-methyl-D-aspartate (NMDA) receptor currents but did not affect non-NMDA receptors.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD378 |
| CAS # | 151776-26-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | SEP-174559; SEP 174559; SEP174559; (S)-DMZ; (S) DMZ; (S)DMZ; (S)-Desmethylzopiclone; (S) Desmethylzopiclone; (S)Desmethylzopiclone |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H15ClN6O3 |
| Exact Mass | 374.0894 |
| Molecular Weight | 374.785 |
| Elemental Analysis | C, 51.28; H, 4.03; Cl, 9.46; N, 22.42; O, 12.81 |
| IUPAC/Chemical Name | (S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate |
| InChi Key | CGSFZSTXVVJLIX-HNNXBMFYSA-N |
| InChi Code | InChI=1S/C16H15ClN6O3/c17-10-1-2-11(21-9-10)23-14(24)12-13(20-4-3-19-12)15(23)26-16(25)22-7-5-18-6-8-22/h1-4,9,15,18H,5-8H2/t15-/m0/s1 |
| SMILES Code | O=C(N1CCNCC1)O[C@@H]2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |