Verucerfont
Verucerfont, also known as GSK561679 and NBI77860, is a CRF-1 antagonist. Verucerfont blocks the CRH-1 receptor, and so reduces ACTH release following chronic stress. It is under investigation as a potential treatment for alcoholism, as chronic stress is often a factor in both development of alcoholism and relapse in recovering alcoholics. It has shown promising results in animal studies but has not been tested in humans.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD424 |
| CAS # | 885220-61-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | GSK561679; GSK-561679; GSK 561679; SK-561,679; GSK561679A; NBI77860; NBI-77860; NBI 77860; Verucerfont. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H26N6O2 |
| Exact Mass | 406.2117 |
| Molecular Weight | 406.49 |
| Elemental Analysis | C, 65.01; H, 6.45; N, 20.68; O, 7.87 |
| IUPAC/Chemical Name | (S)-3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-(1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)pyrazolo[1,5-a]pyrimidin-7-amine |
| InChi Key | VKHVAUKFLBBZFJ-SFHVURJKSA-N |
| InChi Code | InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1 |
| SMILES Code | CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |