Isoguvacine HCl
Isoguvacine is a GABAA receptor agonist. It binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay. It inhibits CA1 population spikes in rat hippocampal slices and high potassium/low magnesium-induced seizures in rat pups. Chronic administration of isoguvacine improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD454 |
| CAS # | 68547-97-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | Isoguvacine HCl; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C6H10ClNO2 |
| Exact Mass | 163.04 |
| Molecular Weight | 163.601 |
| Elemental Analysis | C, 44.05; H, 6.16; Cl, 21.67; N, 8.56; O, 19.56 |
| IUPAC/Chemical Name | 1,2,3,6-tetrahydropyridine-4-carboxylic acid hydrochloride |
| InChi Key | SUWREQRNTXCCBL-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H |
| SMILES Code | O=C(O)C1=CCNCC1.Cl |
| Appearance | Solid powder |
| Purity | >95% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |
| Availability | 2 Weeks |