Tat-NR2B9c TFA
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-P0117A-5 mg |
| CAS # | 1834571-04-8 |
| Pricing | 5 mg, USD $216.0 |
| Synonyms | Tat-NR2Bct TFA; NA-1 TFA |
| MWt | 2632.9 |
| Formula | C₁₀₅H₁₈₈N₄₂O₃₀.C₂HF₃O₂ |
| Biological Activity | Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1]. |
| Purity | 99.67% |