CRT0066101 free base
CRT0066101 is a PRKDs inhibitor. CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27Kip1 and phospho-CDK1 (Thr14/Tyr15). CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD160 |
| CAS # | 956121-30-5 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | CRT0066101 HCl; CRT-0066101; CRT 0066101; CRT0066101 free base |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H19ClN4O |
| Exact Mass | 342.1247 |
| Molecular Weight | 342.827 |
| Elemental Analysis | C, 63.06; H, 5.59; Cl, 10.34; N, 16.34; O, 4.67 |
| IUPAC/Chemical Name | 2-[4-[[(2R)-2-Aminobutyl]amino]-2-quinazolinyl]-4-chloro-phenol |
| InChi Key | OC1=CC=C(Cl)C=C1C2=NC(NC[C@H](N)CC)=C3C=CC=CC3=N2 |
| InChi Code | InChI=1S/C18H19ClN4O/c1-2-12(20)10-21-17-13-5-3-4-6-15(13)22-18(23-17)14-9-11(19)7-8-16(14)24/h3-9,12,24H,2,10,20H2,1H3,(H,21,22,23)/t12-/m1/s1 |
| SMILES Code | OC1=CC=C(Cl)C=C1C2=NC(NC[C@H](N)CC)=C3C=CC=CC3=N2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |