L-778123
L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
| Supplier | BOC Sciences |
|---|---|
| Product # | 183499-57-2 |
| Pricing | Inquire |
| Cas | 183499-57-2 |
| Molecular Weight | 405.88 |
| Molecular Formula | C22H20ClN5O |
| Canonical SMILES | C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl |