Tosedostat-[d5]
Labelled Tosedostat. Tosedostat is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2 with IC50 values are > 1000, > 5000, > 10000 and > 30000 nM for aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively. Phase 2. Tosedostat potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-007478 |
| Pricing | Inquire |
| Cas | 1217844-03-5 |
| Molecular Weight | 411.5 |
| Molecular Formula | C21H25D5N2O6 |
| Canonical SMILES | CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2 |