| Supplier |
CD BioSciences |
| Product # |
AMA-0684 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:50)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Mouse
|
| Gene ID |
5528
|
| UniProt ID |
|
| Source/Isotype |
Mouse IgG1
|
| MW (Target) |
66 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PPP2R5D protein.
|
| Background |
Protein Phosphatase 2A subunit isoform R5-δ (PPP2R5D) belongs to the R5/B'/B56 family of the regulatory subunit B of serine/threonine phosphatase 2A PPP2R5D (B-δ) is structurally related to the other components of subunit B, B-α. PPP2R5D lacks the WD-40 repeats that are important for protein-protein interaction Structural differences may contribute to distinct down stream effects and directing PP2A nuclear localization Current evidence suggests that in contrast to B-α, PPP2R5D modulates the TGF-β/Actividin/Nodal signaling pathways by restricting the downstream activities of the type I TGF-β receptors, ALK4, and ALK5.
|