PIN1 inhibitor API-1

Supplier MedChemExpress
Product # HY-116716-10 mM * 1 mL
CAS # 680622-70-2
Pricing 10 mM * 1 mL, USD $201.0
Biological Activity PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].
MWt 366.3
Formula C₁₅H₁₃F₃N₆O₂
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