MG-277
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-130122-5 mg |
| CAS # | 2411085-89-5 |
| Pricing | 5 mg, USD $1850.0 |
| Biological Activity | MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity[1]. |
| Purity | 98.94% |
| MWt | 774.71 |
| Formula | C₄₁H₄₂Cl₂FN₅O₅ |