AZD-8529 mesylate
AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1401 |
| CAS # | 1314217-69-0 (mesylate) |
| Pricing | Customizable size, Inquiry |
| Synonym | AZD-8529; AZD8529; AZD 8529; AZD-8529 mesylate |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C25H28F3N5O6S |
| Exact Mass | 487.18 |
| Molecular Weight | 583.5832 |
| Elemental Analysis | C, 51.45; H, 4.84; F, 9.77; N, 12.00; O, 16.45; S, 5.49 |
| IUPAC/Chemical Name | 7-methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one mesylate |
| InChi Key | HRHCPVNKPOTCGB-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C24H24F3N5O3.CH4O3S/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25,26)27;1-5(2,3)4/h2-5,10-11,28H,6-9,12-14H2,1H3;1H3,(H,2,3,4) |
| SMILES Code | O=C1N(CC2=CC=C(OC(F)(F)F)C=C2)CC3=C1C(C)=CC(C4=NC(CN5CCNCC5)=NO4)=C3.OS(=O)(C)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |