CGP 55845
CGP 55845 is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1446 |
| CAS # | 150175-54-5 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | CGP 55845; CGP-55845; CGP55845 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H22Cl2NO3P |
| Exact Mass | 401.0714 |
| Molecular Weight | 402.25 |
| Elemental Analysis | C, 53.75; H, 5.51; Cl, 17.63; N, 3.48; O, 11.93; P, 7.70 |
| IUPAC/Chemical Name | Phosphinic acid, ((2S)-3-(((1S)-1-(3,4-dichlorophenyl)ethyl)amino)-2- hydroxypropyl)(phenylmethyl)- |
| InChi Key | ZODSPDOOCZZEIM-BBRMVZONSA-N |
| InChi Code | InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1 |
| SMILES Code | O=P(CC1=CC=CC=C1)(C[C@@H](O)CN[C@H](C2=CC=C(Cl)C(Cl)=C2)C)O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |