| Background |
mTORC1 kinase complex is a critical component in the regulation of cell growth Its activity is modulated by energy levels, growth factors, and amino acids The four related GTPases, RagA, RagB, RagC, and RagD, have been shown to interact with raptor in mTORC1 These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals A protein complex consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, and LAMTOR3/MAPKSP1 has been identified to interact with and recruit the four Rag GTPases to the surface of lysosomes.
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