Vestipitant
Vestipitant, also known as GW597599, is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) receptor blockade in the alleviation of anxiety and, possibly, depression. It is under development as a potential antiemetic and anxiolytic drug, and as a treatment for tinnitusand insomnia.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1313 |
| CAS # | 334476-46-9 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | GW597599; GW 597599; GW-597599; Vestipitant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H24F7N3O |
| Exact Mass | 491.18076 |
| Molecular Weight | 491.44 |
| Elemental Analysis | C, 56.21; H, 4.92; F, 27.06; N, 8.55; O, 3.26 |
| IUPAC/Chemical Name | (2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide |
| InChi Key | SBBYBXSFWOLDDG-JLTOFOAXSA-N |
| InChi Code | InChI=1S/C23H24F7N3O/c1-13-8-18(24)4-5-19(13)20-12-31-6-7-33(20)21(34)32(3)14(2)15-9-16(22(25,26)27)11-17(10-15)23(28,29)30/h4-5,8-11,14,20,31H,6-7,12H2,1-3H3/t14-,20-/m1/s1 |
| SMILES Code | O=C(N1[C@@H](C2=CC=C(F)C=C2C)CNCC1)N([C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)C |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |