Tyk2-IN-7

Ask the supplier | View on supplier's website
Supplier MedChemExpress
Product # HY-126242S
CAS # 1609391-90-3
Pricing inquire
Biological Activity
  • Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively.
  • Tyk2-IN-7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain.
  • Tyk2-IN-7 (Compound 48) provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].
MWt 401.46
Formula C₁₈H₁₅D₃N₆O₃S
Feedback