uPAcs-Luffin-β immunotoxin
This immunotoxin was achieved by conjugating/fusing the uPAcs to loofah toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lung cancer cells and the toxin enters cells by receptor-mediated endocytosis. Then loofah toxin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of lung cancer.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L071L |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Human |
| Target | PLAU |
| Species Reactivity | Human |