Human Anti-HIV-1 Env Recombinant Antibody (clone ch103)
Recombinant Human Antibody (ch103) is capable of binding to HIV-1 Env, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 Env mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 Env mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized approximately 55% of HIV-1 isolates, and its co-crystal structure with the HIV-1 envelope protein gp120 revealed a new loop-based mechanism of CD4-binding-site recognition.
Supplier | Creative Biolabs |
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Product # | PABL-145 |
Pricing | Inquiry |
Host | Human |
Target | HIV-1 Env |
Species Reactivity | HIV-1 |
Type | Human IgG1, κ |
Applications | ELISA, Neut, FuncS |
Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |