Activin A Receptor Type 2B (ACVR2B) Antibody
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3 to 4-fold higher affinity for the ligand than activin A type II receptor.
Supplier | Abbexa Ltd. |
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Product # | abx033182-400UL |
Pricing | 400 µl USD $601.75 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | ELISA, WB |
UniProt Primary AC | Q13705 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |