Nintedanib, Free Base (BIBF1120, Intedanib, Vargatef, CAS 656247-17-5), >99%

LC Laboratories' Product Number N-9077 - Nintedanib, Free Base (BIBF1120, Intedanib, Vargatef, CAS 656247-17-5, CAS 928326-83-4), >99% - for research use only. Nintedanib (BIBF1120, Intedanib, Vargatef) is an indolinone derivative that potently inhibits vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) kinase activity in enzymatic assays. It blocks mitogen-activated protein kinase and Akt signaling pathways in three cell types contributing to angiogenesis, namely endothelial cells, pericytes, and smooth muscle cells, and it inhibits cell proliferation with an EC50 of 10-80 nM. Nintedanib significantly decreased blood vessel area and inhibited tumour growth. A reproducible hepatic perfusion index (HPI) was determined by using quantified gadopentetate dimeglumine (Gd-DTPA) concentration. The HPI decreased significantly at 28 days after treatment with intedanib. HPI may be useful for monitoring antiangiogenic treatment response of hepatic metastases. Another CAS number previously assigned to Nintedanib, Free Base, namely 928326-83-4 has been deleted by CAS and is no longer in use. This research compound is the free base form of nintedanib. We also offer the ethanesulfonate salt form; please see Nintedanib, Ethanesulfonate Salt, Cat. No. N-9055. This nintedanib product is the free base, whose CAS number is given above. The CAS number of the Nintedanib, Ethanesulfonate Salt form is 656247-18-6. Nintedanib is the active ingredient in the drug formulation designated by the trade name Vargatef®. This drug has been used in human clinical trials for patients with non-small cell lung, colorectal, uterine, endometrial, ovarian, and cervical cancer and multiple myeloma. NOTE: THE NINTEDANIB, ETHANESULFONATE SALT RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT VARGATEF®, AND IS NOT FOR HUMAN USE.

• Supplier: LC Laboratories
• Product #: N-9077
• Sku #: N-9077_1g