Idelalisib, Free Base (CAL-101, GS-1101, Zydelig, CAS 870281-82-6), >99%

LC Laboratories' Product Number I-7447 - Idelalisib, Free Base (CAL-101, GS-1101, Zydelig, CAS 870281-82-6), >99% - for research use only. Idelalisib, also known as CAL-101 or GS-1101, is a selective inhibitor of phosphoinositide 3-kinase (PI3K) P110δ with an IC50 of 2.5 nM. It also inhibits other class I PI3Ks including p110α (IC50 = 820 nM), p110β (IC50 = 565 nM), and p110γ (IC50 = 89 nM). Idelalisib inhibited constitutive PI3K signaling and induced apoptosis in a broad range of immature and mature B-cell malignancies. Idelalisib showed a unique pattern of response with early lymphocytosis concomitant with reduction in lymph-node and spleen size in patients with chronic lymphocytic leukemia. Idelalisib blocked proliferation of LB and INA-6 multiple myeloma (MM) cell lines and patient MM cells, associated with inhibition of Akt phosphorylation. Idelalisib inhibited MM cell growth induced by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cell coculture. Combination of idelalisib and bortezomib induced synergistic cytotoxicity against MM cells. However, idelalisib did not inhibit survival of normal peripheral blood mononuclear cells. Please note that, as of October 1, 2014, Shanghai Biochempartner is using an incorrect and confusing CAS number for Idelalisib, Free Base. The correct CAS number for Idelasilib, Free Base is given above. The correct CAS number for the compound that this vendor is confusing with Idelasilib is 870281-17-7. This compound differs from Idelalisib by having a methyl group instead of the ethyl group in Idelalisib. The incorrect CAS number being used by this vendor for the methyl analog, 1146702-54-6, has been deleted by Chemical Abstracts Service and is no longer in use. Idelalisib is the active ingredient in the drug product sold under the trade name Zydelig®. This drug is currently approved in at least one country for use in patients with different types of leukemia. NOTE: THE IDELALISIB, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT ZYDELIG®, AND IS NOT FOR HUMAN USE.

• Supplier: LC Laboratories
• Product #: I-7447
• Sku #: I-7447_2g