Bortezomib, Free Base (Velcade, MG-341, PS-341, CAS 179324-69-7), 99%

LC Laboratories' Product Number B-1408 - Bortezomib, Free Base (Velcade, MG-341, PS-341), 99% - for research use only. Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory activity against other enzymes or receptors. In a study with the National Cancer Institute's panel of 60 human cell lines, bortezomib showed a mean IC50 of 7 nM as tested by SRB analysis. Bortezomib is progressive in preclinical models of human prostate cancer, while its effects on apoptosis versus angiogenesis are cell type dependent. Bortezomib caused comparable growth suppression in LNCaP-Pro5 and PC3M-Pro4 cells with an IC90 of 10 nM. Bortezomib inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM. Bortezomib is the active ingredient in the drug sold under the trade name Velcade®. This drug has been approved in at least one country to treat multiple myeloma.

• Supplier: LC Laboratories
• Product #: B-1408
• Sku #: B-1408_10g