EGFR-IN-12
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-17499-10 mM * 1 mL |
| CAS # | 879127-07-8 |
| Pricing | 10 mM * 1 mL, USD $198.0 |
| Biological Activity | EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity[1][2]. |
| Purity | 99.49% |
| MWt | 413.4 |
| Formula | C₂₁H₁₈F₃N₅O |