K-252a
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-N6732-1 mg |
| CAS # | 99533-80-9 |
| Pricing | 1 mg, USD $330.0 |
| Synonyms | SF2370; Antibiotic K 252a; Antibiotic SF 2370 |
| MWt | 467.47 |
| Formula | C₂₇H₂₁N₃O₅ |
| Biological Activity | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3]. |
| Purity | ≥99.0% |