Dizocilpine maleate
Dizocilpine, also known as MK-801 or (+)-MK-801, is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and likely has dissociative anesthetic properties, but it is not used clinically for this purpose due to the discovery of brain lesions, called Olney's lesions (see below), in test rats. Dizocilpine is the most frequently used non-competitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD159 |
| CAS # | 77086-22-7 (maleate) |
| Pricing | Customizable size, Inquiry |
| Synonym | MK-801; MK 801; MK801; MK-801 maleate; Dizocilpine maleate. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H19NO4 |
| Molecular Weight | 337.375 |
| Elemental Analysis | C, 71.20; H, 5.68; N, 4.15; O, 18.97 |
| IUPAC/Chemical Name | 5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate |
| InChi Key | QLTXKCWMEZIHBJ-BTJKTKAUSA-N |
| InChi Code | InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| SMILES Code | CC1(N2)C3=CC=CC=C3CC2C4=CC=CC=C14.O=C(O)/C=C\C(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |
| Availability | 2 Weeks |