Losmapimod
Losmapimod, also know as GW856553 or GW856553X or GSK-AHAB, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and antipsychotic effects in animal studies, with the mechanism thought to involve increased neurogenesis probably related to BDNF release.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD935 |
| CAS # | 585543-15-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | Losmapimod; GW856553; GW-856553; GW 856553; GSK-AHAB; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C22H26FN3O2 |
| Exact Mass | 383.20091 |
| Molecular Weight | 383.46 |
| Elemental Analysis | C, 68.91; H, 6.83; F, 4.95; N, 10.96; O, 8.34 |
| IUPAC/Chemical Name | 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide. |
| InChi Key | KKYABQBFGDZVNQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28) |
| SMILES Code | O=C(C1=CC=C(C2=CC(C(NC3CC3)=O)=CC(F)=C2C)N=C1)NCC(C)(C)C |
| Appearance | white solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |