Anti-TFRC immunotoxin 454A12 (IgG)-Gel
This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating leptomeningeal carcinomatosis.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G068G |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | TFRC |
| Species Reactivity | Human |