Human Anti-PCSK9 Recombinant Antibody (clone J16)
Recombinant Human Antibody (J16) is capable of binding to PCSK9, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PCSK9 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-PCSK9 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody, J16, potently inhibit PCSK9 binding to the LDLR extracellular domain and PCSK9-mediated down-regulation of LDLR in vitro.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABC-196 |
| Pricing | Inquiry |
| Host | Human |
| Target | PCSK9 |
| Species Reactivity | Human |
| Type | Human IgG |
| Applications | IF, IP, WB, ELISA |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |