Triciribine-[13C,d3]
Labelled Triciribine. Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-007511 |
| Pricing | Inquire |
| Molecular Weight | 324.32 |
| Molecular Formula | C12[13C]H13D3N6O4 |
| Canonical SMILES | CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N |