Pomaglumetad
Pomaglumetad, also known as LY-404,039, is a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pomaglumetad has potential antipsychotic and anxiolytic effects. LY-404,039 is intended as a treatment for schizophrenia and other psychotic and anxiety disorders by modulating glutamatergic activity and reducing presynaptic release of glutamate at synapses in limbic and forebrain areas relevant to these disorders. The specific binding of LY-404,039 to human cloned mGlu receptors has been found to be highest for mGluR2 (Ki = 149 +/- 11 nM) and relatively high for mGluR3 (Ki = 92 +/-14 nM).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD331 |
| CAS # | 635318-11-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | LY-404039; LY 404039; LY404039; LY-404,039; LY404,039; LY 404,039; Pomaglumetad |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C7H9NO6S |
| Exact Mass | 235.0151 |
| Molecular Weight | 235.21 |
| Elemental Analysis | C, 35.75; H, 3.86; N, 5.96; O, 40.81; S, 13.63 |
| IUPAC/Chemical Name | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide |
| InChi Key | AVDUGNCTZRCAHH-MDASVERJSA-N |
| InChi Code | InChI=1S/C7H9NO6S/c8-7(6(11)12)1-15(13,14)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 |
| SMILES Code | O=S1(C[C@](C(O)=O)(N)[C@@H]2[C@@H](C(O)=O)[C@@H]21)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |