Rosonabant
Rosonabant aslo known as E-6776, is a CB1 receptor antagonist/inverse agonist that was under investigation by Esteve as an appetite suppressant for the treatment of obesity. Development of the drug for clinical use was apparently halted shortly after the related CB1 antagonist rimonabant was discontinued, likely due to the reports of severe psychiatric adverse effects such as anxiety, depression, and suicidal ideation associated with it and with similarly-acting agents.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD362 |
| CAS # | 861151-12-4 |
| Pricing | Customizable size, Inquiry |
| Synonym | E-6776; E 6776; E6776; Rosonabant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H21Cl3N4O |
| Exact Mass | 450.0781 |
| Molecular Weight | 451.776 |
| Elemental Analysis | C, 55.83; H, 4.69; Cl, 23.54; N, 12.40; O, 3.54 |
| IUPAC/Chemical Name | (R)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide |
| InChi Key | WMMMJGKFKKBRQR-HXUWFJFHSA-N |
| InChi Code | InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29)/t20-/m1/s1 |
| SMILES Code | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)[C@@H](C3=CC=C(Cl)C=C3)C1)NN4CCCCC4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |