A412997
A412997 is a selective D4R agonist. -412997 showed significant dose-dependent efficacy in both models. A-412997 binds with high affinity to rat dopamine D4 and human dopamine D4.4 receptors (Ki=12.1 and 7.9 nM, respectively). In contrast to the dopamine D4 receptor agonists PD168077 and CP226269, A-412997 showed a better selectivity profile and no affinity <1000 nM for other dopamine receptors or any other proteins in a panel of seventy different receptors and channels. In functional assays using calcium flux, A-412997 was a potent full agonist at rat dopamine D4 receptors (28.4 nM, intrinsic activity=0.83) and did not activate rat dopamine D2L receptors.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1369 |
| CAS # | 630116-49-3 |
| Pricing | Customizable size, Inquiry |
| Synonym | A412997; A-412997; A 412997; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H23N3O |
| Exact Mass | 309.1841 |
| Molecular Weight | 309.413 |
| Elemental Analysis | C, 73.76; H, 7.49; N, 13.58; O, 5.17 |
| IUPAC/Chemical Name | N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide |
| InChi Key | JFCDMGGMCUKHST-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23) |
| SMILES Code | O=C(NC1=CC=CC(C)=C1)CN2CCC(C3=NC=CC=C3)CC2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |