db/db Mouse
An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and the inclusion of 106 nt of intronic sequence in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | DMM-001005 |
| Pricing | Inquiry |
| Synonyms | Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP |
| Category | Mouse Models |
| disease type | T2DM |
| Strain Name | B6.BKS(D)-Leprdb/J |
| Background Strain | B6.BKS |
| SPF | Yes |
| Research Application | Leptin resistance; insulin resistance; obesity; and type 2 diabetes. |
| Target Name | Lepr |
| Gene ID | 16847 |