Meglumine
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0598 |
| Pricing | , Inquire for price |
| product1 | Excipients for Liquid Dosage Form |
| Molecular Formula | C7H17NO5 |
| Molecular Weight | 195.21 |
| Applications | Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. |
| Safety | Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg |
| Incompatibilities | Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizid. |
| Synonyms | Meglumin; meglumina; megluminum; 1-methylamino-1-deoxy-Dglucitol; N-methylglucamine; N-methyl-D-glucamine |
| CAS Number | 6284-40-8 |
| Category | Organic Base: pH regulator; Solubilizing Agents |
| UNII | 6HG8UB2MUY |
| Chemical Name | 1-Deoxy-1-(methylamino)-D-glucitol |
| Grade | Pharmceutical Excipients |
| Administration route | Intramuscular injection; Intravenous injection; Oral |
| Dosage Form | Injection, tablet, capsule |
| Stability and Storage Conditions | Meglumine does not polymerize or dehydrate unless heated above 150℃ for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. |
| Source and Preparation | Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. |