Meglumine
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
Supplier | CD Formulation |
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Product # | PE-0598 |
Pricing | , Inquire for price |
product1 | Excipients for Liquid Dosage Form |
Molecular Formula | C7H17NO5 |
Molecular Weight | 195.21 |
Applications | Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. |
Safety | Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg |
Incompatibilities | Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizid. |
Synonyms | Meglumin; meglumina; megluminum; 1-methylamino-1-deoxy-Dglucitol; N-methylglucamine; N-methyl-D-glucamine |
CAS Number | 6284-40-8 |
Category | Organic Base: pH regulator; Solubilizing Agents |
UNII | 6HG8UB2MUY |
Chemical Name | 1-Deoxy-1-(methylamino)-D-glucitol |
Grade | Pharmceutical Excipients |
Administration route | Intramuscular injection; Intravenous injection; Oral |
Dosage Form | Injection, tablet, capsule |
Stability and Storage Conditions | Meglumine does not polymerize or dehydrate unless heated above 150℃ for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. |
Source and Preparation | Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. |