Meglumine

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
Supplier CD Formulation
Product # PE-0598
Pricing , Inquire for price
product1 Excipients for Liquid Dosage Form
Molecular Formula C7H17NO5
Molecular Weight 195.21
Applications Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
Safety Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg
Incompatibilities Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizid.
Synonyms Meglumin; meglumina; megluminum; 1-methylamino-1-deoxy-Dglucitol; N-methylglucamine; N-methyl-D-glucamine
CAS Number 6284-40-8
Category Organic Base: pH regulator; Solubilizing Agents
UNII 6HG8UB2MUY
Chemical Name 1-Deoxy-1-(methylamino)-D-glucitol
Grade Pharmceutical Excipients
Administration route Intramuscular injection; Intravenous injection; Oral
Dosage Form Injection, tablet, capsule
Stability and Storage Conditions Meglumine does not polymerize or dehydrate unless heated above 150℃ for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
Source and Preparation Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
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