Pardoprunox HCl
Pardoprunox, also known as SLV-308; DU-126891; SME-308, is dopamine D2/5-HT1A receptor agonist potentially for the treatment of Parkinson's disease. It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned. Pardoprunox acts as a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%). It also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD371 |
| CAS # | 269718-83-4 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | SLV-308; SLV 308; SLV308; DU-126891; SME-308; DU126891; SME308; Pardoprunox; Pardoprunox HCl. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C12H16ClN3O2 |
| Molecular Weight | 269.73 |
| Elemental Analysis | C, 53.44; H, 5.98; Cl, 13.14; N, 15.58; O, 11.86 |
| IUPAC/Chemical Name | 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one hydrochloride |
| InChi Key | NQRIKTDKFHAOKC-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C12H15N3O2.ClH/c1-14-5-7-15(8-6-14)10-4-2-3-9-11(10)17-12(16)13-9;/h2-4H,5-8H2,1H3,(H,13,16);1H |
| SMILES Code | O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl |
| Appearance | Pale mauve solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |