Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105)
Recombinant Human Antibody (F105) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti- HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti- HIV-1 gp120 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. F105 is a neutralizing, CD4–binding site (CD4BS) antibody, binding to gp120 occurred primarily through heavy-chain interactions, which were similar in many respects to those of CD4. F105 recognized conformational shifts in the position of the V1/V2 stem, resulting in a V1/V2 orientation poorly compatible with the functional viral spike.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABW-160 |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | Human IgG |
| Applications | FC, Neut, WB, ELISA |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |